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David Letterman - Host (David Letterman), Paul Shaffer - Musical Director (Paul Shaffer), Alan Kalter - Announcer (Alan Kalter), Biff Henderson - Stage Manager (Biff Henderson), Regis Philbin (Regis Philbin), Barbara Gaines - Executive Producer (Barbara Gaines), Tony Mendez - Cue Card Boy (Tony Mendez), Al Chez - Horn Section Yay-Sayer #2 (Al Chez), Jack Hanna (Jack Hanna), Tom Malone - Horn Section Yay-Sayer #1 (Tom Malone), Bruce Kapler - Horn Section Yay-Sayer #3 (Bruce Kapler), Rupert Jee (Rupert Jee), Pat Farmer - Stagehand (Pat Farmer), Stanley Cronkite (Johnny Dark), Jeff Altman (Jeff Altman), Joe Grossman - Staff Writer (Joe Grossman), Chris Elliott - Guest (Chris Elliott), Marv Albert (Marv Albert), Andrea Sande - Late Show Model (Andrea Sande), Bruce Willis - Guest (Bruce Willis), Tom Brokaw (Tom Brokaw), Will Lee - Creepy Screamer (Will Lee), Jude Brennan - Executive Producer (Jude Brennan), Alec Baldwin - Guest (Alec Baldwin), Tom Hanks - Guest (Tom Hanks), The Guy that beats up Alan (Brian Donahue), Anna Jack - Hula Hoop Girl (Anna Jack), Bill Wendell - Announcer (Bill Wendell), Tom Dreesen (Tom Dreesen), PC Computer (Gerard Mulligan), Kiva Kahl - Grinder Girl (Kiva Kahl), Andy Kindler (Andy Kindler), Dave Dorsett - Camera Operator (Dave Dorsett), Barbara Walters (Barbara Walters), Martin Short - Guest (Martin Short), Susan Hum - Costume Designer (Susan Hum), Bill Murray (Bill Murray), Richard Simmons (Richard Simmons), Billy Crystal - Guest (Billy Crystal), Bill Scheft (Bill Scheft), Amy Sedaris - Guest (Amy Sedaris), Bill Cosby - Guest (Bill Cosby), Nathan Lane - Guest (Nathan Lane), Martha Stewart (Martha Stewart), Tom Arnold (Tom Arnold), Adam Sandler (Adam Sandler), Robin Williams - Guest (Robin Williams), Brian Regan (Brian Regan), George Clarke - Weight Loss Challenger (George Clarke), Mayor Michael Bloomberg (Gary Mintz), Ray Romano (Ray Romano), Don Rickles - Guest (Don Rickles), Matthew Broderick - Guest (Matthew Broderick), Rute - Late Show Model (Rute), Phil McGraw (Phil McGraw), Steve Martin - Guest (Steve Martin), Jake Johannsen (Jake Johannsen), Jon Stewart (Jon Stewart), Ticket Scalper (Michael Z. McIntee), Donald Trump - Guest (Donald Trump), Sarah Jessica Parker - Guest (Sarah Jessica Parker), Mike Singletary (Art Kelly), Will Ferrell - Guest (Will Ferrell), Elvis Costello (Elvis Costello), Charles Grodin - Guest (Charles Grodin), Norm MacDonald (Norm MacDonald), Samuel L. Jackson - Guest (Samuel L. Jackson), Jim Gaffigan (Jim Gaffigan), Jay Thomas - Guest (Jay Thomas), Ricky Gervais - Guest (Ricky Gervais), Brian Williams (Brian Williams), Michael J. Fox - Guest (Michael J. Fox), Julia Roberts - Guest (Julia Roberts), Kevin Spacey - Guest (Kevin Spacey), Al Franken (Al Franken), Ben Stiller - Guest (Ben Stiller), Kelsey Grammer (Kelsey Grammer), Themselves - Musical Guest (Foo Fighters), John Witherspoon (John Witherspoon), Tina Fey - Guest (Tina Fey), David Spade (David Spade), Drew Barrymore - Guest (Drew Barrymore), John Travolta - Guest (John Travolta), Darlene Love (Darlene Love), Harry Connick Jr. - Guest (Harry Connick Jr.), Kelly Ripa (Kelly Ripa), Jerry Seinfeld - Guest (Jerry Seinfeld), Mike Myers (Mike Myers), Willie Nelson (Willie Nelson), Howard Stern (Howard Stern), Dan Rather (Dan Rather), Eddie Brill (Eddie Brill), Felicia Michele Collins - CBS Orchestra: Guitar (Felicia Michele Collins), Will Smith - Guest (Will Smith), John Goodman - Guest (John Goodman), David Brenner (David Brenner), Matt Damon - Guest (Matt Damon), Julianna Margulies - Guest (Julianna Margulies), Vince Vaughn - Guest (Vince Vaughn), George Clooney - Guest (George Clooney), Sheryl Crow (Sheryl Crow), Emmylou Harris - Musical Guest (Emmylou Harris), Lyle Lovett (Lyle Lovett), Bonnie Hunt (Bonnie Hunt), Denis Leary - Guest (Denis Leary), Natalie Portman - Guest (Natalie Portman), Harrison Ford - Guest (Harrison Ford), Tony Randall (Tony Randall), Stephanie Birkitt (Stephanie Birkitt), Chris 'Mad Dog' Russo (Chris 'Mad Dog' Russo), Keith Olbermann (Keith Olbermann), Kevin James - Guest (Kevin James), Denzel Washington - Guest (Denzel Washington), Bill O'Reilly (Bill O'Reilly), John McCain (John McCain), Chris Rock (Chris Rock), Anderson Cooper - Guest (Anderson Cooper), Michael Keaton - Guest (Michael Keaton), Mark Wahlberg - Guest (Mark Wahlberg), Ellen DeGeneres (Ellen DeGeneres), Helen Hunt - Guest (Helen Hunt), Tim Robbins - Guest (Tim Robbins), Tony Bennett - Guest (Tony Bennett), Kathie Lee Gifford (Kathie Lee Gifford), George Miller (George Miller), Dorothy Mengering - Top Ten List Presenter (Dorothy Mengering), Jim Carrey - Guest (Jim Carrey), Sean 'Diddy' Combs (Sean 'Diddy' Combs), Julie Chen (Julie Chen), Jennifer Lopez - Guest (Jennifer Lopez), Sylvester Stallone - Guest (Sylvester Stallone), Rosie Perez - Guest (Rosie Perez), Shannon Eis (Shannon Eis), Roger Ebert - Guest (Roger Ebert), Gene Szymanski - Disruptive Staffer (Gene Szymanski), Voiceover Announcer (Edd Hall), Amanda Peet - Guest (Amanda Peet), Paul Rudd - Guest (Paul Rudd), Barry Sonnenfeld - Guest (Barry Sonnenfeld), Jamie Foxx - Guest (Jamie Foxx), David Duchovny (David Duchovny), Jimmie Walker (Jimmie Walker), Bob Sarlatte (Bob Sarlatte), John Mayer (John Mayer), Dana Carvey - Guest (Dana Carvey), Sandra Bullock - Guest (Sandra Bullock), Natalie Merchant (Natalie Merchant), Rosie O'Donnell - Guest (Rosie O'Donnell), Bernie Madoff (Peter 'Pete' Fatovich), Harold - Energy Saving Expert (Harold Larkin), Paris Hilton - Guest (Paris Hilton), Tracy Morgan (Tracy Morgan), Stephen Colbert - Guest (Stephen Colbert), Paul Teutul Sr. (Paul Teutul Sr.), Julianne Moore - Guest (Julianne Moore), Bill Clinton - Guest (Bill Clinton), Kate Hudson - Guest (Kate Hudson), Ryan Adams - Musical Guest (Ryan Adams), Katie Holmes (Katie Holmes), Neil Patrick Harris - Guest (Neil Patrick Harris), Jeff Goldblum - Guest (Jeff Goldblum), David Hyde Pierce - Guest (David Hyde Pierce), Sting - Musical Guest (Sting), Tori Amos (Tori Amos), Dolly Parton (Dolly Parton), Danny DeVito (Danny DeVito), Tom Selleck (Tom Selleck), Gene Siskel (Gene Siskel), John McEnroe (John McEnroe), Isabella Rossellini - Guest (Isabella Rossellini), David Sanborn (David Sanborn), Marilu Henner (Marilu Henner), Fran Drescher - Guest (Fran Drescher), Themselves (Dave Matthews), Model (Mary Alexandra Stiefvater), Kathy Mavrikakis (Kathy Mavrikakis), Rachel Maddow (Rachel Maddow), Jamie Oliver (Jamie Oliver), Nick Griffin (Nick Griffin), Robert Downey Jr. - Guest (Robert Downey Jr.), Jack Black (Jack Black), Alicia Keys (Alicia Keys), Uma Thurman - Guest (Uma Thurman), Claire Danes - Guest (Claire Danes), Salma Hayek - Guest (Salma Hayek), Queen Latifah - Guest (Queen Latifah), John Mellencamp (John Mellencamp), Roseanne Barr - Guest (Roseanne Barr), Faith Hill (Faith Hill), Mary Tyler Moore - Guest (Mary Tyler Moore), Elle Macpherson (Elle Macpherson), Jewel Kilcher (Jewel Kilcher), Jeff Daniels - Guest (Jeff Daniels), Bonnie Raitt (Bonnie Raitt), Todd Seda - Disruptive Staffer (Todd Seda), Luke Wilson (Luke Wilson), Kiefer Sutherland - Guest (Kiefer Sutherland), Bill Maher (Bill Maher), Whoopi Goldberg - Guest (Whoopi Goldberg), Johnny Depp - Guest (Johnny Depp), Susan Sarandon - Guest (Susan Sarandon), Woody Harrelson - Guest (Woody Harrelson), Halle Berry - Guest (Halle Berry), Lisa Kudrow - Guest (Lisa Kudrow), Derek Jeter (Derek Jeter), Steven Wright (Steven Wright), Lenny Kravitz - Musical Guest (Lenny Kravitz), Rudy Giuliani (Rudy Giuliani), Andy Dick (Andy Dick), Al Green (Al Green), Themselves - Musical Guest (Blues Traveler), Brett Butler (Brett Butler), Ricki Lake (Ricki Lake), Darrell Hammond (Darrell Hammond), Mitch Hedberg (Mitch Hedberg), Dave's Diner Waitress (Mary Ann Hannon), Teri Hatcher (Teri Hatcher), Charles Barkley (Charles Barkley), Katie Couric (Katie Couric), Norah Jones - Guest (Norah Jones), Ashton Kutcher - Guest (Ashton Kutcher), Frank Caliendo (Frank Caliendo), Demi Moore - Guest (Demi Moore), Julia Louis-Dreyfus - Guest (Julia Louis-Dreyfus), Courteney Cox - Guest (Courteney Cox), Renée Zellweger - Guest (Renée Zellweger), Conan O'Brien (Conan O'Brien), Louis C.K. - Guest (Louis C.K.), Dennis Quaid - Guest (Dennis Quaid), John Cusack - Guest (John Cusack), Joaquin Phoenix - Guest (Joaquin Phoenix), Lou Reed (Lou Reed), Bono - Guest (Bono), Sean Hayes - Guest (Sean Hayes), Robert Klein (Robert Klein), Martin Lawrence - Guest (Martin Lawrence), Wendy Liebman (Wendy Liebman), Nanci Griffith (Nanci Griffith), Trisha Yearwood (Trisha Yearwood), Andie MacDowell (Andie MacDowell), Geena Davis - Guest (Geena Davis), Jeff Foxworthy (Jeff Foxworthy), Artie Lange - Guest (Artie Lange), Jonah Hill (Jonah Hill), Craig Ferguson (Craig Ferguson), Jessica Biel - Guest (Jessica Biel), Steve Carell - Guest (Steve Carell), James Franco - Guest (James Franco), Snoop Dogg (Snoop Dogg), Nicolas Cage - Guest (Nicolas Cage), Jake Gyllenhaal - Guest (Jake Gyllenhaal), Barack Obama - Guest (Barack Obama), Penn Jillette (Penn Jillette), Paul Teutul Jr. (Paul Teutul Jr.), Steve Earle - Musical Guest (Steve Earle), Teller (Teller), Jada Pinkett Smith (Jada Pinkett Smith), Joan Rivers - Guest (Joan Rivers), Richard Lewis - Guest (Richard Lewis), Sarah Vowell (Sarah Vowell), John Fogerty - Musical Guest (John Fogerty), Ben Harper (Ben Harper), Cyndi Lauper - Guest (Cyndi Lauper), Themselves - Musical Guest (Wilco), Wyclef Jean - Musical Guest (Wyclef Jean), Matthew Perry (Matthew Perry), Gwyneth Paltrow - Guest (Gwyneth Paltrow), Kristin Davis (Kristin Davis), Hillary Clinton - Guest (Hillary Clinton), Kathy Griffin - Guest (Kathy Griffin), Janeane Garofalo (Janeane Garofalo), Dan Patrick - Guest (Dan Patrick), Themselves - Musical Guest (Green Day), Ellen Barkin - Guest (Ellen Barkin), Jimmy Fallon (Jimmy Fallon), Tom Cruise - Guest (Tom Cruise), Ted Danson - Guest (Ted Danson), Todd Rundgren (Todd Rundgren), Alan Jackson (Alan Jackson), Alanis Morissette (Alanis Morissette), John Popper (John Popper), Joan Lunden (Joan Lunden), Dave Chappelle (Dave Chappelle), Jason Alexander - Guest (Jason Alexander), Tony Danza (Tony Danza), Luke Perry - Guest (Luke Perry), Mia Farrow - Guest (Mia Farrow), B.B. King (B.B. King), Louis J. Aronne - Weight Loss Coach (Louis J. Aronne), Leslie Moonves (Leslie Moonves), Jay Johnson - Digital Producer (Jay Johnson), Dave Grohl (Dave Grohl), Dave's Nurse (Jane Gabbert), Paula Abdul (Paula Abdul), Mike Golic (Mike Golic), Mike Greenberg (Mike Greenberg), Seth Rogen - Guest (Seth Rogen), Greg Kinnear (Greg Kinnear), Jennifer Connelly - Guest (Jennifer Connelly), Jim Parsons - Guest (Jim Parsons), Seth Meyers - Guest (Seth Meyers), Tommy Johnagin - Guest Comic (Tommy Johnagin), Anne Heche - Guest (Anne Heche), Jennifer Garner - Guest (Jennifer Garner), Kristin Chenoweth - Guest (Kristin Chenoweth), Dwayne Johnson - Guest (Dwayne Johnson), Jason Bateman (Jason Bateman), Billy Bob Thornton - Guest (Billy Bob Thornton), Paul Newman - Guest (Paul Newman), Drew Carey (Drew Carey), Jennifer Aniston - Guest (Jennifer Aniston), Nicole Kidman - Guest (Nicole Kidman), Reese Witherspoon - Guest (Reese Witherspoon), Edie Falco - Guest (Edie Falco), Kirstie Alley - Guest (Kirstie Alley), Eric Ripert (Eric Ripert), Todd Barry (Todd Barry), Christina Aguilera - Guest (Christina Aguilera), Brooke Shields - Guest (Brooke Shields), Hugh Grant (Hugh Grant), Bob Dole (Bob Dole), Liv Tyler - Guest (Liv Tyler), Scarlett Johansson - Guest (Scarlett Johansson), Mike Judge (Mike Judge), Melissa Etheridge - Guest (Melissa Etheridge), Bumped Musical Guest #3 (The Edge), Jimmie Johnson (Jimmie Johnson), Davey Faragher - Performer (Davey Faragher), Kevin Pollak (Kevin Pollak), Mary Chapin Carpenter (Mary Chapin Carpenter), Terry Bradshaw (Terry Bradshaw), Mandy Patinkin - Guest (Mandy Patinkin), Themselves (Hootie & the Blowfish), Pauly Shore (Pauly Shore), Kevin Kline (Kevin Kline), Vince Gill (Vince Gill), Chazz Palminteri (Chazz Palminteri), George Carlin - Guest (George Carlin), Art Donovan (Art Donovan), Jeff Gordon (Jeff Gordon), Marc Maron (Marc Maron), Naomi Campbell (Naomi Campbell), Megan Mullally - Guest (Megan Mullally), Adam Levine (Adam Levine), Tom Catusi - Late Show Video Operator (Tom Catusi), Mark Odgers - 53rd Street Slam-Dunker (Mark Odgers), Bill Burr (Bill Burr), Kyra Sedgwick - Guest (Kyra Sedgwick), Jay Z (Jay Z), Michael Cera - Guest (Michael Cera), Kaley Cuoco - Guest (Kaley Cuoco), Brad Paisley - Musical Guest (Brad Paisley), Michael Bublé - Musical Guest (Michael Bublé), Russell Crowe - Guest (Russell Crowe), Madonna - Guest (Madonna), Lance Armstrong (Lance Armstrong), Colin Farrell - Guest (Colin Farrell), Amy Poehler - Guest (Amy Poehler), Jason Segel - Guest (Jason Segel), Will Arnett - Guest (Will Arnett), Jason Sudeikis - Guest (Jason Sudeikis), Tim McGraw (Tim McGraw), Gary Mule Deer (Gary Mule Deer), Mary J. Blige - Guest (Mary J. Blige), Lucinda Williams (Lucinda Williams), Al Gore - Guest (Al Gore), Glenn Close - Guest (Glenn Close), Kevin Bacon - Guest (Kevin Bacon), Charlize Theron - Guest (Charlize Theron), Catherine Zeta-Jones (Catherine Zeta-Jones), Jimmy Kimmel (Jimmy Kimmel), Debra Messing - Guest (Debra Messing), Hugh Jackman - Guest (Hugh Jackman), Jessica Simpson (Jessica Simpson), Dustin Hoffman - Guest (Dustin Hoffman), Kid Rock (Kid Rock), David Sedaris (David Sedaris), David Gray (David Gray), Charlie Sheen - Guest (Charlie Sheen), Bob Newhart (Bob Newhart), Mariah Carey - Guest (Mariah Carey), Albert Brooks - Guest (Albert Brooks), Sharon Stone - Guest (Sharon Stone), Pierce Brosnan - Guest (Pierce Brosnan), Jackie Chan - Guest (Jackie Chan), Sarah Michelle Gellar - Guest (Sarah Michelle Gellar), Matthew McConaughey - Guest (Matthew McConaughey), Themselves - Musical Guest (Stone Temple Pilots), LL Cool J (LL Cool J), Anthony Clark (Anthony Clark), Eddie Vedder - Musical Guest (Eddie Vedder), Beck (Beck), Harry Hill (Harry Hill), Themselves - Musical Guest (Pearl Jam), Diana Krall (Diana Krall), Rosanne Cash (Rosanne Cash), Themselves (Counting Crows), Themselves - Musical Guest (The Pretenders), Alison Krauss (Alison Krauss), Anton Fig - CBS Orchestra: Drums (Anton Fig), Anthony Hamilton (Anthony Hamilton), Robert Duvall - Guest (Robert Duvall), Aaron Neville (Aaron Neville), Pete Townshend (Pete Townshend), Bob Saget (Bob Saget), Paul Simon (Paul Simon), Martin Mull (Martin Mull), Ray Liotta - Guest (Ray Liotta), Sinéad O'Connor - Guest (Sinéad O'Connor), Heather Locklear (Heather Locklear), Travis Tritt (Travis Tritt), Gabriel Byrne (Gabriel Byrne), Laurence Fishburne (Laurence Fishburne), Cybill Shepherd - Guest (Cybill Shepherd), Jerry Van Dyke (Jerry Van Dyke), Rita Wilson - Guest (Rita Wilson), Kirsten Dunst - Guest (Kirsten Dunst), David Schwimmer (David Schwimmer), Patti Smith (Patti Smith), Curator of the Louvres Museum (Francis Dumaurier), Bumped Musical Guest #2 (Larry Mullen Jr.), Various Characters (Mark Delabarre), Mary Barclay - Assistant to David Letterman (Mary Barclay), Taylor Hawkins (Taylor Hawkins), Nate Mendel (Nate Mendel), Chris Shiflett (Chris Shiflett), Pat Smear (Pat Smear), R.J. (R.J. Fried), Kate Walsh (Kate Walsh), Themselves - Musical Guest (U2), Justin Bieber (Justin Bieber), Jessica Alba - Guest (Jessica Alba), Amy Adams - Guest (Amy Adams), Jeremy Piven - Guest (Jeremy Piven), Russell Brand - Guest (Russell Brand), Matthew Fox - Guest (Matthew Fox), Bill Hader - Guest (Bill Hader), Emma Watson - Guest (Emma Watson), Mindy Kaling - Guest (Mindy Kaling), Mike Birbiglia - Comedian (Mike Birbiglia), Kim Kardashian West - Guest (Kim Kardashian West), Themselves - Musical Guest (The Black Keys), Themselves - Musical Guest (Maroon 5), Sarah Silverman - Guest (Sarah Silverman), Larry Miller (Larry Miller), Matt Lauer (Matt Lauer), Brian Kiley (Brian Kiley), LeBron James (LeBron James), Ludacris - Musical Guest (Ludacris), Alan Zweibel - Guest (Alan Zweibel), Eddie Murphy - Guest (Eddie Murphy), Garry Shandling - Guest (Garry Shandling), Tobey Maguire - Guest (Tobey Maguire), Kate Winslet - Guest (Kate Winslet), Meryl Streep - Guest (Meryl Streep), Jude Law - Guest (Jude Law), Anne Hathaway - Guest (Anne Hathaway), Joe Torre (Joe Torre), Ringo Starr (Ringo Starr), Cobie Smulders (Cobie Smulders), John Hiatt (John Hiatt), Keanu Reeves - Guest (Keanu Reeves), Jeff Caldwell (Jeff Caldwell), Lupe Fiasco (Lupe Fiasco), James Taylor (James Taylor), Themselves - Musical Guest (The Black Crowes), Themselves - Musical Guest (Queens of the Stone Age), Emma Thompson - Guest (Emma Thompson), Cameron Diaz - Guest (Cameron Diaz), Chevy Chase (Chevy Chase), Patricia Arquette - Guest (Patricia Arquette), Meg Ryan - Guest (Meg Ryan), Gillian Anderson - Guest (Gillian Anderson), Brad Garrett (Brad Garrett), Lucy Liu - Guest (Lucy Liu), Kate Beckinsale - Guest (Kate Beckinsale), Zooey Deschanel - Guest (Zooey Deschanel), Lindsay Lohan - Guest (Lindsay Lohan), Bev Tanner (Bev Tanner), Themselves (Soul Asylum), Calvert DeForest (Calvert DeForest), Martin Scorsese - Guest (Martin Scorsese), Elton John - Guest (Elton John), Themselves - Musical Guest (The Flaming Lips), Themselves - Guest Performer (Garbage), Tom Waits (Tom Waits), Al Lubel (Al Lubel), Serena Williams - Guest (Serena Williams), Joseph Arthur - Musical Guest (Joseph Arthur), Nick Offerman - Guest (Nick Offerman), Gloria Estefan (Gloria Estefan), PJ Harvey (PJ Harvey), Warren Zevon (Warren Zevon), LeAnn Rimes (LeAnn Rimes), Themselves - Musical Guest (Hanson), Themselves - Musical Guest (Dixie Chicks), Julian Casablancas (Julian Casablancas), Sally Field - Guest (Sally Field), Dwight Yoakam (Dwight Yoakam), Paul Reiser (Paul Reiser), George Foreman (George Foreman), Rich Hall (Rich Hall), Connie Chung (Connie Chung), Bryant Gumbel (Bryant Gumbel), Marisa Tomei - Guest (Marisa Tomei), Sam Donaldson (Sam Donaldson), Evander Holyfield (Evander Holyfield), Cindy Crawford (Cindy Crawford), Sinbad (Sinbad), Phil Hartman (Phil Hartman), Rob Lowe - Guest (Rob Lowe), Kurt Russell - Guest (Kurt Russell), David Byrne (David Byrne), Stevie Nicks (Stevie Nicks), Magic Johnson (Magic Johnson), Anthony Hopkins - Guest (Anthony Hopkins), Gary Sinise - Guest (Gary Sinise), Dan Aykroyd - Guest (Dan Aykroyd), Cokie Roberts (Cokie Roberts), Richard Harris (Richard Harris), Harland Williams (Harland Williams), Wesley Snipes (Wesley Snipes), James Carville (James Carville), Tracy Chapman - Musical Guest (Tracy Chapman), Ziggy Marley (Ziggy Marley), Themselves - Musical Guest (The Chieftains), Jesse Jackson (Jesse Jackson), Al Roker (Al Roker), Themselves - Musical Guest (R.E.M.), Shania Twain - Guest (Shania Twain), Themselves (The Wallflowers), Jon Favreau (Jon Favreau), Kenny Sheehan - Reading 'Oprah' Transcript (Kenny Sheehan), Robert Borden - Writer (Robert Borden), Antonio Banderas - Guest (Antonio Banderas), Cate Blanchett - Guest (Cate Blanchett), Moby (Moby), Tom Cavanagh (Tom Cavanagh), Brittany Murphy (Brittany Murphy), Albert Hammond Jr. (Albert Hammond Jr.), Greg Giraldo (Greg Giraldo), Sid McGinnis - CBS Orchestra: Guitar (Sid McGinnis), Deborah Lynn (Deborah Lynn), Bruce Willis Shooting Victim (Richard Scheckman), Attorney Jim Jackoway (Brian Teta), French Tutor for Dave Dorsett (Karen Weatherwax), Harry Joseph Letterman - Cameo (Harry Joseph Letterman), Bumped Musical Guest #1 (Adam Clayton), Michael Strahan - Guest (Michael Strahan), Rachael Ray - Guest (Rachael Ray), Evangeline Lilly - Guest (Evangeline Lilly), Shia LaBeouf - Guest (Shia LaBeouf), Katherine Heigl - Guest (Katherine Heigl), Blake Lively - Guest (Blake Lively), Jason Randal (Jason Randal), Maggie Gyllenhaal - Guest (Maggie Gyllenhaal), Christina Applegate - Guest (Christina Applegate), Michael Douglas - Guest (Michael Douglas), Patrick Dempsey - Guest (Patrick Dempsey), Simon Baker (Simon Baker), Marcia Cross - Guest (Marcia Cross), Mary-Louise Parker - Guest (Mary-Louise Parker), Betty White - Guest (Betty White), John Krasinski - Guest (John Krasinski), Danica Patrick (Danica Patrick), Ken Burns (Ken Burns), Themselves - Musical Guest (Band of Horses), Ne-Yo - Musical Guest (Ne-Yo), Vera Farmiga - Guest (Vera Farmiga), Themselves - Musical Guest (TV on the Radio), Themselves - Musical Guest (Kings of Leon), Cher - Guest (Cher), Richard Gere - Guest (Richard Gere), Viggo Mortensen - Guest (Viggo Mortensen), Nicole Richie (Nicole Richie), Jane Fonda - Guest (Jane Fonda), Andy Samberg - Guest (Andy Samberg), Ryan Reynolds - Guest (Ryan Reynolds), Johnny Knoxville (Johnny Knoxville), Randy Jackson (Randy Jackson), Rachel Weisz - Guest (Rachel Weisz), Jenna Fischer - Guest (Jenna Fischer), Bryan Cranston - Guest (Bryan Cranston), Emma Stone - Guest (Emma Stone), Melissa McCarthy - Guest (Melissa McCarthy), Laura Dern - Guest (Laura Dern), Sue Johanson (Sue Johanson), Judy Greer - Guest (Judy Greer), Kristen Wiig - Guest (Kristen Wiig), Selena Gomez - Guest (Selena Gomez), Sacha Baron Cohen - Guest (Sacha Baron Cohen), Wynton Marsalis (Wynton Marsalis), Reba McEntire - Guest (Reba McEntire), Darius Rucker (Darius Rucker), CeeLo Green (CeeLo Green), Themselves - Musical Guest (The Strokes), Avril Lavigne (Avril Lavigne), Themselves - Musical Guest (Interpol), Themselves - Musical Guest (Yeah Yeah Yeahs), Tom Russell (Tom Russell), Themselves - Musical Guest (The Airborne Toxic Event), Joan Jett - Guest (Joan Jett), Quentin Tarantino - Guest (Quentin Tarantino), Nicholas Turturro (Nicholas Turturro), Jeff Bridges - Guest (Jeff Bridges), Kelly Preston (Kelly Preston), Pamela Anderson (Pamela Anderson), Meredith Vieira (Meredith Vieira), Courtney Love - Guest (Courtney Love), David Arquette (David Arquette), Marg Helgenberger (Marg Helgenberger), Lauren Graham - Guest (Lauren Graham), Julia Stiles - Guest (Julia Stiles), Zach Braff (Zach Braff), Jon Cryer - Guest (Jon Cryer), Robert Plant (Robert Plant), Bon Jovi (Bon Jovi), Teri Garr - Guest (Teri Garr), Shelby Lynne (Shelby Lynne), Slash (Slash), Jimmy Buffett (Jimmy Buffett), Doc Severinsen (Doc Severinsen), Pete Sampras (Pete Sampras), Shaquille O'Neal (Shaquille O'Neal), Greg Fitzsimmons (Greg Fitzsimmons), Kristen Johnston - Guest (Kristen Johnston), Jerry Springer (Jerry Springer), Rufus Wainwright - Guest (Rufus Wainwright), Keri Russell - Guest (Keri Russell), Dennis Regan (Dennis Regan), Jenna Elfman (Jenna Elfman), Eugene Levy (Eugene Levy), Michael Teutul (Michael Teutul), Kevin Harvick - Top Twelve List Presenter (Kevin Harvick), M. Ward - Musical Guest (M. Ward), Mark Teixeira (Mark Teixeira), Johnny Galecki - Guest (Johnny Galecki), Jennifer Lawrence - Guest (Jennifer Lawrence), Themselves - Musical Guest (Spin Doctors), Sarah McLachlan (Sarah McLachlan), Themselves - Musical Guest (Sonic Youth), Randy Travis (Randy Travis), Marty Stuart - Musical Guest (Marty Stuart), Themselves - Musical Guest (Everclear), Themselves - Musical Guest (Barenaked Ladies), Macy Gray (Macy Gray), Themselves - Musical Guest (The Roots), Sarah Billington - Guest (Sarah Billington), Ron Howard - Guest (Ron Howard), Britney Spears (Britney Spears), Jackson Browne (Jackson Browne), Larry King (Larry King), Jerry Lewis - Guest (Jerry Lewis), Jim Belushi (Jim Belushi), Carly Simon - Guest (Carly Simon), Lily Tomlin - Guest (Lily Tomlin), Chris Isaak (Chris Isaak), Bryan Adams (Bryan Adams), Clint Black (Clint Black), Penelope Ann Miller (Penelope Ann Miller), Jon Lovitz (Jon Lovitz), Bob Einstein (Bob Einstein), Aretha Franklin - Musical Guest (Aretha Franklin), Seal - Musical Guest (Seal), Spike Lee - Guest (Spike Lee), Anthony LaPaglia (Anthony LaPaglia), Reggie Miller (Reggie Miller), Walter Cronkite (Walter Cronkite), Michael Lomonaco (Michael Lomonaco), Dennis Hopper (Dennis Hopper), Jennifer Jason Leigh - Guest (Jennifer Jason Leigh), Patrick Stewart - Guest (Patrick Stewart), Helena Bonham Carter (Helena Bonham Carter), Kenneth Branagh - Guest (Kenneth Branagh), Themselves (Indigo Girls), Wynonna Judd (Wynonna Judd), Merrill Markoe (Merrill Markoe), Jean-Claude Van Damme (Jean-Claude Van Damme), Tim Allen (Tim Allen), David Copperfield (David Copperfield), Themselves (Phish), Christopher Walken - Guest (Christopher Walken), Kathleen Madigan (Kathleen Madigan), Liam Gallagher (Liam Gallagher), Noel Gallagher (Noel Gallagher), David Bowie - Guest (David Bowie), Jonathan Katz (Jonathan Katz), Brian Wilson (Brian Wilson), Mel Gibson - Guest (Mel Gibson), Themselves (Oasis), Bill Pullman (Bill Pullman), Alicia Silverstone - Guest (Alicia Silverstone), Anthony Edwards - Guest (Anthony Edwards), Themselves (Collective Soul), Sparky Mortimer (Sparky Mortimer), Alex Rodriguez (Alex Rodriguez), Sarah Ferguson (Sarah Ferguson), Mira Sorvino (Mira Sorvino), Peyton Manning (Peyton Manning), Bill DeLace - Head of Security (Bill DeLace), Missy Elliott (Missy Elliott), Dane Cook (Dane Cook), Heidi Klum (Heidi Klum), Fiona Apple (Fiona Apple), Farrah Fawcett - Guest (Farrah Fawcett), Ice Cube - Guest (Ice Cube), Eddie Izzard (Eddie Izzard), Themselves (The Piedmont Bird Callers), Carson Daly (Carson Daly), Themselves - Musical Guest (Train), Grant Paulsen (Grant Paulsen), Nikolai Fraiture (Nikolai Fraiture), Fabrizio Moretti (Fabrizio Moretti), Nick Valensi (Nick Valensi), Homer Simpson (Dan Castellaneta), Dave Johnson - Phone Interviewee (Dave Johnson), Al Norwood - Boom Operator (Al Norwood), Sketch Comedian (Tracey B. 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