Nový seriál o Spider-Manovi začíná v době, kdy už ho svět zná jeden rok. Už zachraňuje životy a poráží protivníky. Nick Fury ze S.H.I.E.L.D. mu právě nabízí možnost pracovat se skutečnými superhrdiny. Spider-Manovými kolegy budou například Nova, White Tiger, Iron Fist nebo Power Man.

Adrian Pasdar, Ashley Eckstein, Ben Diskin, Billy West, Bumper Robinson, Caitlyn Taylor Love, Cam Clarke, Cameron Boyce, Chi McBride, Chris Cox, Christopher Daniel Barnes, Clancy Brown, Clark Gregg, Corey Burton, Cree Summer, Danny Jacobs, Dante Basco, Daryl Sabara, David Boat, David Kaye, David Sobolov, Debby Ryan, Dee Bradley Baker, Diedrich Bader, Donald Glover, Dove Cameron, Dwight Schultz, Eliza Dushku, Elizabeth Henstridge, Eric Bauza, Facundo Reyes, Fred Tatasciore, Freddy Rodríguez, George Takei, Greg Cipes, Greg Grunberg, Grey Griffin, Iain De Caestecker, Imari Williams, J.K. Simmons, Jack Coleman, James Arnold Taylor, James Marsters, Jason Marsden, JB Blanc, Jeff Bennett, John DiMaggio, Jon Polito, Jonathan Adams, Karan Brar, Keith Szarabajka, Keone Young, Kevin Michael Richardson, Kimberly Brooks, Laura Bailey, Liam O"Brien, Logan Miller, Maria Canals-Barrera, Mary Kate Wiles, Matt Lanter, Maurice LaMarche, Max Mittelman, Michael Clarke Duncan, Milo Ventimiglia, Misty Lee, Nika Futterman, Nolan North, Oded Fehr, Ogie Banks, Olivia Holt, Paul Scheer, Peter Lurie, Peyton List, Phil LaMarr, Phil Morris, Rick D. Wasserman, Rob Paulsen, Robert Clotworthy, Robert Patrick, Robin Atkin Downes, Roger Craig Smith, Rose McGowan, Ross Lynch, Scott Porter, Seth Green, Sheb Wooley, Skai Jackson, Stan Lee, Steve Blum, Steven Weber, Tara Strong, Terry Crews, Trevor Devall, Troy Baker, Wendie Malick, Will Friedle