Constantine dokáže v ľuďoch vidieť anjelov a démonov, no jeho duša je upísaná peklu. Rozhodne sa život plný zla opustiť, no toto rozhodnutie mu nevydrží dlho. Démoni sa totiž zamerajú na dcéru jeho kamaráta Liv (Lucy Griffiths známa z True Blood) a jemu nezostáva nič iné, než sa vrátiť späť do boja.
Tvorcovia obsadili do role hlavného hrdinu Matta Ryana (Myšlienky vraha, Vikingovia) a sľubujú návrat ku koreňom komiksu.

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